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pm | | asics gel nimbus (2nd Sep 20 at 5:51am UTC) | | ASICS enlisted Taica as its official asics shoes supplier and first announced the new tech in 1986 under the name Alpha GEL System. Boom! The space-age cushioning system was welcomed by the running community as the key to reducing impact-related injuries, reducing vibration and perhaps even shaving a few key seconds off those long-distance running records. The audience was listening, now all ASICS had to do was package their GEL system into a banging silhouette. Get your freak on. Japanese runners received their first taste of walking on GEL with the Japan-only release of the Freaks Alpha model in 1986. The jogging shoe followed the classic ASICS runner formula, paired with Alpha GEL technology in key impact zones on the heel and forefoot, together with stylistic updates: An elongated heel section provided extra grip on the tracks, while "freaky" style was added by ways of reflective silver hits.
Also make sure to watch the amazing launch video showing folks across Berlin raising their shoes to the sun. Powerful stuff! What a catch! For the grand opening of his Brooklyn-based KITH store, Ronnie Fieg pulled a special ASICS GEL-Lyte III release out of the water. The strictly limited "Salmon Toes" featured a asics shoes womens navy upper with the toe box dipped in a salmon colorway. Only 72 pairs were available on September 30, and finding one swimming around the resale streams today is a rare sight. Let's hit the outdoors. Celebrating the fifth anniversary of Rotterdam sneaker store Woei's, they teamed up with ASICS on the trail-inspired GEL-Lyte III "Cervidae." One of those collabs that illustrate the power of materials asics shoes men to render the same silhouette in an entirely different light, this one also replaced the upper eyelets with trail hooks to take the GEL-Lyte III for a walk through nature.
All models of the run featured painting in the hand-lettered style of U.S. artist Kris Ruhs together with individual numbers on the heel. Pretty enough to put in a display case? First things first. Before the GEL-Lyte silhouette saw the light of day, 1986 marked the arrival of GEL technology in ASICS footwear. Celebrating the 30th anniversary, the company dropped the Gel-Lyte III and the Gel-Lyte V as well as the GT-Cool Xpress, which was the first shoe with visible Gel-Elements in the early 1990s. All three silhouettes are covered in black, which is broken by light blue accents and which is a asics running shoes sharp contrast to the clear white midsole. Upscale materials round out a nice birthday drop, and whet people's appetites for more festive releases. Taking it back to the classics.
But for the 30th anniversary of the silhouette that started it all, ASICS is bringing back the GEL-Lyte Original for the first time in history. And staying close to the classic, the colorway is the original white, black, and bright orange plus reflective accents while the silhouette shines in all its retro glory. Officially dropping on July 7, 2017, this one made the cover of our current SNEAKERS issue as our way of saying congrats to 30 years and running. Happy Anniversary! Background and Purpose: Although recent studies have indicated that acid-sensing ion channels (ASICs) may play an important role in suppressing status epilepticus (SE) in rats, the precise mechanism is unclear. We attempted to investigate the antiepileptic effect of amiloride in SE rats and its mechanism.
Methods: Rats with seizures induced by Li-pilocarpine were randomly divided into four groups, phosphate buffer saline (PBS) group, amiloride group, levetiracetam group and acidic liquid group, respectively. The electroencephalogram (EEG) of each group was recorded. Then rats treated with different drugs (2 h after amiloride or PBS injection or 1 h after PBS injection) and a normal control group was selected for reverse transcription-polymerase chain reaction (RT-PCR). The expression of ASIC1a, ASIC3 and sodium-hydrogen exchanger (NHE) in each group was detected. Results: Amiloride reduced the frequency of discharge in 60~90 min after injection significantly. In acidic liquid group, the epileptic discharge was increased in 0~30 min.
Moreover, the expression of ASIC1a, ASIC3 and NHE was obviously increased in the SE groups. Compared with SE groups, the expression of ASIC1a and ASIC3 mRNA in amiloride group decreased asics gel nimbus significantly. While NHE mRNA expression in the SE groups showed no significant difference. Conclusion: Amiloride inhibited pilocarpine-induced SE and the anti-epileptic mechanism was associated with deactivation of the ASIC1a and ASIC3 instead of NHE in rats. It was reported that amiloride had low potential to be used as a future analgesic or neuroprotective agent in human subjects due to its nonspecificity for various ion channels and ion exchange systems [ 8 ]. However, the structure of amiloride may be chemically modified to produce a molecule that specifically blocks ASICs, or  at least has more selectivity to these ion channels. | |
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